When your instincts tell you something is wrong, trust them and act accordingly. If your instincts were right, you will probably survive the attack. If they were wrong, no harm is done, and you got in some valuable practice for the next time.
When a human predator attacks, you will probably only have time for one course of action, so it must be effective the first time it is used. The predator will not let you use it again, and you will probably not get another chance to try a different tactic.
Human predators are not impressed by you high kicks, physical size, strength, are even a weapon you may have. They are only impressed by any pain you may cause them. The more it hurts them, the more they are impressed. Insure that any defensive tactic you use causes the predator intense pain.
Human predators usually hunt in packs, similar to wolves. For every one that you see, there are probably more waiting to pounce. Therefore, always expect there to be more than one predator. The leader of the pack will usually act first, but the whole pack may attack in unison. Predators who hunt alone are usually the most dangerous. Since they do not have a backup pack, their initial attack must be fierce, deadly, and effective, which makes your reaction even more vital.